ZOMETA Infusion

The recommended dose of ZOMETA for patients with impaired renal function at baseline should be adjusted based on creatinine clearance. Use our convenient creatinine clearance calculator.

Infusion With ZOMETA

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The instructions below are also available in a convenient wall chart for your office. To order a complimentary copy of the wall chart, use our Order Form. In addition, we have an Infusion Log available in PDF format for recording patient information. This document requires Adobe Reader® to open and print. If you do not already have this program on your computer, you can download it free.

Step 1 - Evaluate Patient
BEFORE INFUSION

• Check for clinical signs of dehydration: skin turgor, thirst, dry mouth, low urine output, weight loss
• Serum creatinine should be measured before each ZOMETA dose and treatment should be withheld for renal deterioration. In the clinical studies, renal deterioration was defined as follows:
• For patients with normal baseline creatinine, an increase of 0.5 mg/dL; for patients with abnormal baseline creatinine, an increase of 1.0 mg/dL
• In the clinical studies, ZOMETA treatment was resumed only when the creatinine returned to within 10% of the baseline value
• Check and record baseline vital signs

Step 2 - Administer ZOMETA
DURING INFUSION

ZOMETA 4 mg/5 mL diluted in 100 mL of solution should be administered as an IV infusion over no less than 15 minutes.*

Observe IV drip rate:

• The ZOMETA drip rate is 133 drops/minute or 33 drops/15 seconds - calculation based on a tubing drip factor of 20 drops/mL
• Count the drops for at least 15 seconds to ensure accurate drip rate

Monitor your patient:

• Check IV site for redness, tenderness, swelling, leakage or temperature elevations
• Encourage patient feedback

AFTER INFUSION

• Discontinue patient IV and properly dispose of materials
• Check IV site and patient's vital signs
• Discuss with patient the potential side effects: flu-like symptoms, muscle pain and tenderness at the site
• Schedule serum creatinine test and date for next infusion before patient leaves
• Complete documentation in patient chart

* For details on preparation and storage of solution, see complete prescribing information.

To order a wall chart containing these infusion instructions, please use our Order Form.